The transport systems of mammalian lysosomes
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چکیده
منابع مشابه
The transport systems of mammalian lysosomes.
X. Amino acid transport systems . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 354 A. Lysosomal cystine transport and cystinosis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 354 B. The cystine dimc~[~,yl esle~ selection technique . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 356 C. Cationic ami...
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Amino acid efflux from highly purified rat liver lysosomes exposed to the methyl ester derivatives of leucine, methionine, tyrosine and cystine was examined. The lysosomal efflux of leucine, methionine and tyrosine was unaffected by the presence of MgATP, whereas cystine efflux was stimulated by MgATP. Exposure of lysosomes to 2 mM-MgATP resulted in lysosomal acidification and a 0.5 pH unit inc...
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Transport of D-glucose was studied in Percoll-gradient-purified rat liver lysosomes. D-Glucose uptake had a Km of 22 mM and a t1/2 of approx. 30 s. D-Fucose, 2-deoxyglucose and methyl alpha-glucoside were the most effective competitors for uptake of D-glucose, although D-galactose, D-mannose, D-xylose and L-fucose also appeared to compete for uptake. L-Glucose was a poor competitor for uptake. ...
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Ways in which other transport systems may compensate for one that is genetically defective are considered. Comparisons of the transport systems of organelles (here the lysosome) with the transport system at the plasma membrane has significant implications for chemotherapy.
متن کاملThe transport of glutamine into mammalian cells.
Glutamine has many important functions in mammalian cells, and glutamine transport across cell membranes has accordingly been extensively studied. In the past few years a number of important glutamine transport proteins have been sequenced and their molecular properties have been characterised. In general, four major transporters are important physiologically. These are known as (i) SNAT3 (Syst...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes
سال: 1991
ISSN: 0304-4157
DOI: 10.1016/0304-4157(91)90002-e